Smoking causes many diseases, including lung and oral cancer. But did smoking directly affects your liver too? Most people even don’t aware of it. In this video, we will learn how smoking is injuries to your liver and how we can prevent it.

Every year millions of people die due to Cigarette smoking or Tobacco chewing. Smoking may affect the liver through inflammatory pathways and may aggravate the pathogenic effects on the liver.
When we smoke a cigarette, it releases 400 chemicals, and Nicotine is the most harmful toxic chemical. These toxic chemicals are very harmful to our bodies. Nicotine is absorbed through the lungs during smoking and rapidly metabolized in the liver, inducing three significant adverse effects.

1. Toxic Effect: Smoking yields chemical substances with cytotoxic potentials. These chemicals created by smoking induce oxidative stress associated with lipid peroxidation, which leads to the activation of stellate cells and the development of fibrosis. In addition, smoking increases the production of pro-inflammatory cytokines (IL-1, IL-6, and TNF-α) involved in liver cell injury. It has been reported that smoking increases fibrosis score and histological activity index in chronic hepatitis C (CHC) patients and contributes to the progression of HBV-related cirrhosis.

Immunogenic Effects: Smoking affects both cell-mediated and hormonal immune responses. Nicotine blocks lymphocyte proliferation and differentiation, including suppressing antibody-forming cells by inhibiting antigen-mediated signaling in T-cells and ribonucleotide reductase. Furthermore, smoking induces apoptosis of lymphocytes by enhancing the expression of the Fas (CD95) death receptor, which allows them to be killed by other cells expressing a surface protein called Fas ligand (FasL). Smoking induces elevation of CD8+ T-cytotoxic lymphocytes, decreases CD4+ cells, impairs NK cell activity, and increases the production of pro-inflammatory cytokines (IL-1, IL-6, TNF-α. Although smoking has long-term adverse effects, cessation of tobacco reverses these effects, such as elevation of NK activity, which is detectable within one month of smoking cessation, the elevation of both antibody- and cell-mediated immune responses, and decreased pro-inflammatory cytokines increased antioxidant activity.

Oncogenic Effects: Smoking yields chemicals with oncogenic potentials such as hydrocarbons, nitrosamine, tar, and vinyl chloride. Cigarette smoking is a significant source of 4-aminobiphenyl, a hepatic carcinogen that has been implicated as a causal risk factor for HCC. Smoking increases the risk of HCC in patients with viral hepatitis. Furthermore, recent data from China and Taiwan have shown an association of smoking with liver cancer independent of HBV status. Tobacco smoking reduces p53, a tumor suppressor gene that is considered “the genome guardian.” Suppression of T-cell responses by Nicotine and tar is associated with decreased surveillance for tumor cells] reported that heavy smokers accumulate excess iron in hepatocytes which induces fibrosis and favors the development of HCC. Smoking is considered a co-factor with HBV and HCV for hepatocarcinogenesis. In addition, suppressed mood, a common feature among heavy smokers, increases the risk of cancer development.

Impact of smoking if you have any liver diseases.
It is crucial to know the impact of smoking if you already have liver diseases like fatty liver, NAFLD, or any Hepatics and does damages in the liver reverse or increase if we stop smoking.
If you have any diseases that mean your liver cells are damaged, smoking increases the severity of these damages. So, it is advisable to quit smoking as soon as possible.
Smoking with alcohol is most harmful, and injuries for your liver increase the risk of diseases, and smoking also affects liver transplants.
Must consult the doctor and get regular health check-ups if you smoke.

About Dr. Bipin Vibhute and this channel:
______________________________________
Dr. Bipin Vibhute is the program director of the Center for Organ Transplants, Sahyadri Hospitals ( Pune, Nashik & Karad ). He is famous for his outstanding surgical skills, great patient rapport, down-to-earth nature, and infectious smile.

Through this channel, we are bringing a lot of information related to the liver, its various diseases, and some important information. So, stay updated, subscribe, like, and share our channel.

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Visit website: https://thelivertransplant.com/

About Dr.Bipin Vibhute and this channel:
______________________________________

Dr. Bipin Vibhute is the program director of the Center for Organ Transplants, Sahyadri Hospitals ( Pune, Nashik & Karad ). He is famous for his outstanding surgical skills, great patient rapport, down-to-earth nature, and infectious smile.

Through this channel, we are bringing a lot of information related to the liver, its various diseases, and some important information. So, stay updated, subscribe, like, and share our channel.

Thanks!

The language used in this video is #Hindi.

Previous Video on SUPERFOOD for Better Liver Health: https://youtu.be/YAWqZxK0zgc

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About Dr.Bipin Vibhute and this channel: ______________________________________

Dr. Bipin Vibhute is the program director of the Center for Organ Transplants, Sahyadri Hospitals ( Pune, Nashik & Karad ). He is famous for his outstanding surgical skills, great patient rapport, down-to-earth nature, and infectious smile.

Through this channel, we are bringing a lot of information related to the liver, its various diseases, and some important information. So, stay updated, subscribe, like, and share our channel.