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Role of Vitamins for the Treatment of Nonalcoholic Steatohepatitis
  • Upper Basement Sahyadri Multispeciality
    Hospital, Karve Road,Deccan Gymkhana, Pune-04
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Role of Vitamins for the Treatment of NASH

by | Jul 24, 2020 | NASH Blog

Nonalcoholic Steatohepatitis is a very common liver disease that bears a resemblance to the alcoholic liver disorder. The similarity occurs in both histologically and clinically. However, NASH takes place in the absence of alcohol consumption. The disorder is more likely to be linked to Type 2 diabetes, hypertension, obesity, and hyperlipidemia. NASH is life-threatening and can get worse if you do not acquire proper medications and diet. According to the expert advice, you can improve your nonalcoholic steatohepatitis symptoms by supplementing your body with the precise form and quantity of vitamins. Here are the significant roles of different vitamins in treating your NASH. 

 

Vitamin E

Along with the consumption of medicines, doctors will suggest you consume Vitamin E in the first place. There are altogether 8 natural Vitamin E forms, which have shown positive results in the treatment of nonalcoholic steatohepatitis. A dose of 800 IU/day of vitamin E daily can fruitfully improve the condition of your liver. Patients who suffer from NASH are more prone to have higher oxidative stress. It can potentially lead to cell death and enlarged lipid peroxidation.

Some researches bring evidence that supplementation of vitamin E can enhance your liver integrity through the downregulation of the hepatitic cluster. However, Vitamin is packed with antioxidants, which might be able to make your condition better. But, before providing vitamin E to the children, it would be better to consult your physician.

 

Vitamin A

Vitamin A involves phospholipids and unsaturated fatty acids. Our liver is the storehouse of Vitamin A and is closely related to adipose tissue. Vitamin A is mostly stored in hepatic stellate cells (HSC) which are also responsible for the development of fibrogenesis. Thus, HSC is activated for becoming a profibrogenic HSC. Then the activated the HSC tends to lose the Vitamin A content.

Apart from vitamin E, Vitamin A also shows some effective results in the treatment of nonalcoholic steatohepatitis. Majorly known as retinoic acid, vitamin A works wonderfully in controlling the adipose tissue. Moreover, several pieces of the study prove the fact that retinoic acid efficiently decreases the adiposity in your liver, which in terms improve the hepatic fat catabolism. Besides, a lot of researches show the beneficial outcome of vitamin A in dealing of the obesity-related health issue. As overweight is a principal reason behind NASH, it will be quite helpful in preventing the complexity by adding the mentioned vitamin in the nonalcoholic steatohepatitis diet.

 

Vitamin B group

Among the eight natural forms of the vitamin B group, only vitamin B12 and B3 have shown positive results in treating nonalcoholic steatohepatitis. Vitamin B3, which is more commonly called niacin, holds a crucial role in managing lipid metabolism. It is responsible for blocking the weight gain in the liver. Moreover, vitamin B3 forms a protective shield before the existing hepatic steatosis. It suggests that the vitamin not only helps in preventing the nonalcoholic steatohepatitis symptoms but also proves to be a possible treatment measure for the preexisted nonalcoholic steatohepatitis. Furthermore, the discussed vitamin B group also helps in reducing the concentration of plasma triglyceride. As a result, you can notice an enhanced condition of the liver enzymes.

On the other hand, according to different studies, a substantial deficiency of vitamin B12 in the mothers creates a high chance of inducing the T2DM and adiposity in the progeny. However, the role of vitamin B12 in treating the already established NASH is yet to discover.

 

Vitamin C and K

The function of vitamin C in treating the condition of nonalcoholic steatohepatitis is somewhat similar to that of vitamin E. Just like Vitamin E, it supplies a great number of antioxidants, which helps in managing the oxidative stress level in NASH. However, except for this, there are not many positive sides of vitamin C in the cure of this chronic liver disorder. On the other side, Vitamin K is proven to have minimal effects in the case of managing lipid metabolism. Nevertheless, a piece of research states that vitamin K is associated with adipocytes, which results in decreasing adult obesity.

 

Vitamin D

Lastly, yet most importantly, Vitamin D has some significant impact on NASH treatment. It is actually a fat-soluble component including the active forms of calcitriol. It is demonstrated to readjust to the immune system. Vitamin D acts as anti-fibrogenic and anti-inflammatory components, which, in fact, will improve the overall liver health of the patients. It further recovers the lipid profile to a great extent, showing positive results in the treatment procedure.

So, these are the potential functions of different vitamins in curing nonalcoholic steatohepatitis. But, before adding it into your diet, make sure to discuss it with your doctor.

Written By

Dr. Bipin Vibhute

Liver and Multi-Organ Transplant Surgeon,

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